Humoral intestinal immunity against Encephalitozoon cuniculi (Microsporidia) infection in mice

Humoral intestinal immunity against Encephalitozoon cuniculi (Microsporidia) infection in mice.

Three strains of mice, BALB/c, IL-12 knock-out (KO) and INF-gamma knock-out, were chosen as an experimental model for the study of intestinal immunity induction against Encephalitozoon cuniculi Levaditi, Nicolau et Schoen, 1923 infection. Mice were infected perorally with 10(7) spores and re-infected with the same dose 70 days after the first infection. The anti-E. cuniculi IgA, IgG and IgM res...

Immune Response Against Encephalitozoon cuniculi Infection

Encephalitozoon cuniculi Infection in Rabbits

intracellular parasite in the phylum Microspora, which is defined by its resistant spore stage. Microsporidia receive little attention in veterinary medical curricula because they are considered important only as parasites of rabbits and fish. Microsporidia are important parasites of humans as well, with some species causing severe disease and death in immunocompromised individuals. Microsporid...

[Experimental Encephalitozoon cuniculi infection in dexamethasone-immunosuppressed mice].

OBJECTIVE Microsporidian Encephalitozoon cuniculi has been recognized as an opportunistic pathogen in immunosuppressed individuals, such as AIDS patients. The objective of the study was to develop pharmacologically immunosuppressed animals as a model of the natural occurring E. cuniculi infection. METHODS Distinct groups of adult Balb-C mice were immunosuppressed with different doses of dexam...

Experimental infection of immunocompetent and immunodeficient mice with Encephalitozoon cuniculi.

An experimental infection with the microsporidian Encephalitozoon cuniculi Levaditi, Nicolau et Schoen, 1923 was studied using a model of immunocompetent BALB/c mice and immunodeficient SCID mice. The course of infection after intraperitoneal inoculation of E. cuniculi spores was evaluated using the presence of spores in peritoneal macrophages as a criterion. First significant decrease in the p...